iCell Water
iCell Water
iCell Water is optimizing cell signaling through modulation of cell volume. Using neutral amino acid osmolytes and creatine to maximize cellular hydration. iCell™ has become a staple in preventing muscle loss in GLP-1 patients by decreasing protein degradation and maintaining beneficial hydration status.
Discussion:
Cellular Pathways
Creatine acts as an osmolyte by acting on the CT1 transporter, which is a member of the (Na++Cl−)-dependent neurotransmitter transporter family.
Glutamine leads to hepatocyte cell swelling due to cumulative, Na+-dependent, uptake into liver cells and activates RVD due to K+, Cl−, and HCO3 − efflux.
Alanine, leucine, and Glycine lead to an increase in cell volume by osmotic pressure and moving through the NA+/K+/Cl anion channels.
Why this matters:
Muscle function is one of the greatest indicators of longevity and decreasing overall mortality risk. Cellular hydration has many benefits when it comes to muscle function and other factors of cellular efficiency, such as protein degradation, increased performance, and cardiovascular benefits.
Clinical Applications:
- Higher intracellular water showed better functional performance independent of muscle mass
- Intracellular water was the main predictor of leg strength and jump performance in highly trained athletes.
- Decrease in ICW during training was found to have reduced power and grip strengt
