{"title":"Heart, Metabolic \u0026 Cellular Health","description":"\u003cp\u003eHeart health, metabolic health, and cellular health overlap more than most supplement categories admit. Arterial calcium, blood lipids, methylation, and oxidative stress at the cellular level all move in different directions, and no single all purpose formula addresses all four. This collection is built around five distinct pathways instead of one broad claim, so you can match the product to the mechanism your protocol is actually targeting.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow to choose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMed Omega Premium:\u003c\/strong\u003e consider this if you want cardiovascular, cognitive, and metabolic support from an omega 3, especially if a standard fish oil hasn't worked for you or digestion makes absorption a concern.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMed Glutathione:\u003c\/strong\u003e consider this if your focus is antioxidant support, detoxification, and immune function at the cellular level.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMed Methylation M+:\u003c\/strong\u003e consider this if you want support for healthy methylation and homocysteine levels already within normal range, particularly relevant if a genetic variation affects how you metabolize folate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMed K2D3:\u003c\/strong\u003e consider this if you're focused on bone density and arterial health, especially alongside vitamin D or calcium, so that calcium gets directed to bone rather than arteries.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMed Niacin Slow Release:\u003c\/strong\u003e consider this if you want support for blood lipids and HDL cholesterol without the flushing that comes with standard niacin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThe mechanism is different for each of these. The Clinical Applications section on each product page names it specifically.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"med-k2d3","title":"Med K2D3","description":"\u003cp\u003eVitamin D helps your body absorb calcium, but without enough vitamin K2 to direct that calcium, it can end up in arteries instead of bone. Med K2D3 pairs a clinically studied 180 mcg dose of bioactive MK-7 with vitamin D3, so the two work together instead of leaving that job half done.*\u003c\/p\u003e\n\u003cp\u003eFormulated for anyone focused on bone density and arterial health, especially alongside vitamin D or calcium supplementation.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eSupports Bone Health*\u003c\/li\u003e\n\u003cli\u003e Promotes Carboxylation of Bone Proteins*\u003c\/li\u003e\n\u003cli\u003eSupports Cardiovascular Health and Arterial Elasticity*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDiscussion:\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin K (as MK-7)\u003c\/strong\u003e\u003cbr\u003eThe body has a limited vitamin K storage capacity compared with other lipophilic vitamins. Vitamin K rapidly depletes without regular dietary intake, yet a small reserve is recycled through a complex oxidation–reduction cycle. The primary function of vitamin K is as a cofactor in producing blood coagulation factors in the liver. Vitamin K also has rather complicated physiological roles in the carboxylation of the proteins involved in promoting bone mineralization and inhibiting arterial calcification.1,2 These physiological roles directly affect bone health and arterial elasticity, respectively.*2,3\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eSupplemental vitamin K can be found in the 3 following forms: synthetic K1;menaquinone-4 (MK-4), which is structurally similar to K1; and natural, long-chain menaquinone-7 (MK-7), which provides the highest vitamin K activity.4 Structural variations between K1 and K2 impact their bioavailability and bioactivity. Menaquinone-7, with its longer side chain, is very hydrophobic. Compared with K1, the physicochemical properties of MK-7 make it highly transportable by plasma lipoproteins, increase its extrahepatic (bones, arteries, etc) availability, and result in its long half-life.2,5,6 Findings from a series of studies comparing the in vivo properties of orally administered K1 and MK-7 demonstrated better bioavailability and utilization of MK-7.*2\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eBone Health\u003c\/strong\u003e\u003cbr\u003eThrough carboxylation, vitamin K activates osteocalcin, the protein needed to bind calcium to the mineral matrix in bone. A 2020 review concluded that MK-7 has the highest bioavailability and the most significant effect on human osteocalcin carboxylation.7 Several studies have demonstrated the efficacy of MK-7 in increasing the carboxylated-to-uncarboxylated osteocalcin (cOC:ucOC) ratio. A high cOC:ucOC ratio is associated with bone health.2,5,6,8 Results from phase 1 of a dose-finding, randomized, double-blind, placebo-controlled trial (N = 60) support that 100 mcg of MK-7 is an effective minimum dose for improving osteocalcin carboxylation. When phase 2 (N = 120) used the placebo or 100-mcg MK-7 dose for 12 weeks with a controlled diet, the test group showed a significant increase in the cOC:ucOC ratio compared with the placebo, confirming the improvement of bone health indices.5 In a randomized, double-blind, placebo-controlled trial in healthy postmenopausal women (N = 244), the test group subjects received 180 mcg of MK-7 daily for 3 years. Supplementation of MK-7 significantly improved vitamin K status, and a decrease was seen in measurements of age-related bone loss.*8\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eArterial\/Cardiovascular Support\u003c\/strong\u003e\u003cbr\u003eVitamin K participates in the carboxylation of matrix GLA protein (MGP), a protein regarded as the most potent inhibitor of arterial calcification, and the intake of long-chain MK is inversely correlated with calcium accumulation in arteries.4,6,9 Conversely, during vitamin K insufficiency, MGP is produced in its inactive form, which is associated with increased cardiovascular risk.10 Arterial calcification makes arteries stiff and \u003cbr\u003eless able to expand and contract. In a double-blind, placebo-controlled trial, 244 healthy postmenopausal women were given 180 mcg\/d of MK-7 and followed for 3 years using pulse wave velocity and ultrasound techniques to determine changes in local carotid and regional aortic stiffness. At the conclusion of the study, the Stiffness Index ß in the MK-7 group had decreased significantly compared with a slight increase in the placebo group. Results confirmed that MK-7 inhibited age-related stiffening of the artery walls and significantly improved vascular elasticity.11 Reviews of the research results evaluating the relationship between vitamin K2 and cardiovascular health suggest a reduction in the mortality rate related to arterial calcification with vitamin K2 intake.*4,12\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eVitamin D (as D3) \u003c\/strong\u003e\u003cbr\u003eVitamin D3 deficiency is common and widespread.13 Many factors can affect D3 biosynthesis, including time of day, seasons, location, smog\/pollution, clothing, skin tone (darker skin requires more sun exposure), sunscreen use, low-cholesterol diets, and certain cholesterol therapies. The body needs vitamin D to absorb calcium, and the importance of vitamin D in skeletal health and bone density is well established. Without adequate absorption, the body must take calcium from its skeletal stores, which weakens existing bone and prevents the formation of strong, new bone. Research results indicate that vitamin D deficiency coexists with low bone mineral density, and vitamin D insufficiency is a common risk factor for osteoporosis associated with increased bone remodeling and low bone mass.14 A pooled analysis evaluating 11 randomized, double-blind, placebo-controlled trials concluded that vitamin D supplementation (\u0026gt;800 IU daily) was favorable in maintaining hip and nonvertebral bone integrity in individuals aged 65 and older.*15\u003c\/p\u003e\n\u003cp\u003eThere is also evidence for the role of vitamin D3 in arterial elasticity. In a double-blind, randomized controlled study, researchers sought to determine the differential effects of vitamin D3 supplementation in a group at high risk for cardiovascular disease. Subjects (N \u003cbr\u003e= 70) with serum 25-hydroxyvitamin D levels ≤20 ng\/mL were randomized to oral supplementation of 600, 2,000, or 4,000 IU\/d of vitamin D3 or placebo for 16 weeks. Vitamin D3 supplementation resulted in dose-dependent increases in serum 25-hydroxyvitamin D concentrations. Doses of 2,000 or 4,000 IU\/d reduced arterial stiffness, as measured by carotid-femoral pulse wave velocity (cfPWV), with the decrease in cfPWV significantly greater in the 4,000-IU\/d group (−10.4%) compared with the 2,000-IU\/d group (−2.0%).*16 Med K2D3 provides MK-7 and vitamin D3 at clinically studied levels to support bone and cardiovascular health in complementary ways.*\u003c\/p\u003e\n","brand":"MedPodLA","offers":[{"title":"Default Title","offer_id":42228384989274,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/MedK2D3_K2-D3Max60c_10540970.png?v=1756356451"},{"product_id":"med-methylation-m","title":"Med Methylation M+","description":"\u003cp\u003eMethylation touches nearly every system in the body, detox, cardiovascular health, neurological function, even how your body clears estrogen and heavy metals, and it depends on a handful of B vitamins working together in their active forms. Med Methylation M+ provides all five, active folate, active B12, active B6, active B2, and trimethylglycine, so the pathway isn't held up waiting on a conversion step your body may not do efficiently.*\u003c\/p\u003e\n\u003cp\u003eFormulated for supporting healthy methylation and homocysteine levels already within normal range, particularly useful alongside genetic variations that affect folate metabolism.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eSupports Cardiovascular and Neurological Health*\u003c\/li\u003e\n\u003cli\u003eSupports the Maintenance of Healthy Homocysteine Levels Already  \u003cbr\u003eWithin Normal Range*\u003c\/li\u003e\n\u003cli\u003eSupports Healthy Methylation of Estrogen, Dopamine, Epinephrine,  \u003cbr\u003eHeavy Metals, and Environmental Toxins*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDiscussion:\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eMed Methylation M+\u003c\/strong\u003e provides 5-methyltetrahydrofolate (active folate), pyridoxal 5'-phosphate (active B6), methylcobalamin (active B12), riboflavin 5'-phosphate (active vitamin B2), and anhydrous betaine (trimethylglycine). These five nutrients promote the process of methylation. Methylation is the addition of a methyl group (a carbon atom \u003cbr\u003ewith three hydrogen atoms attached) to proteins, enzymes, chemicals, DNA, or amino acids like homocysteine. It is a vital and fundamental process that takes place in many biochemical pathways involving detoxification, cardiovascular health, neurological health, eye health, muscle health, bone health, and redox balance. Effective methylation also has roles in the biosynthesis and breakdown of catecholamines, such as epinephrine. This is an important aspect of healthy adrenal functioning.*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eFolic Acid (as calcium folinate and 5-methyltetrahydrofolate).\u003c\/strong\u003e This B vitamin has important roles in detoxification, nervous system function, breast tissue health, prenatal development, and the conversion of homocysteine back to methionine. In its active form, folic acid serves as a donor of methyl groups. Providing the combination of calcium \u003cbr\u003efolinate and 5-methyltetrahydrofolate (5-MTHF) allows optimal utilization of folic acid by bypassing metabolic steps to bioactivity.[1] In fact, 5-MTHF is the form into which the body must convert all other forms of folic acid before it can be used. In this formula, 5-MTHF is provided as calcium folinate and Quatrefolic®. Quatrefolic is proven to have greater \u003cbr\u003estability, solubility, and bioavailability over the calcium salt forms of 5-MTHF.*Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with large doses of folic acid can \"force\" its conversion to the more active form, 5-MTHF may be the preferred form to support healthy folate status. This may be especially true in those with certain variations in folate metabolism or digestion that \u003cbr\u003ecan affect the conversion of folic acid to 5-MTHF.[2-4] Folate is stored in the red blood cells, where levels have been shown to be higher after supplementation with 5-MTHF compared to folic acid and placebo. Patients given 5 mg of 5-MTHF experienced plasma levels 700% greater than patients given folic acid.[5] In another study, authors concluded that 5-MTHF should be the primary choice of supplementation to support healthy homocysteine levels already within the normal range.*[6]\u003c\/p\u003e\n\u003cp\u003e \u003cbr\u003e\u003cstrong\u003eTrimethylglycine (as anhydrous betaine)\u003c\/strong\u003e found in several tissues in humans, trimethylglycine acts as an alternative methyl donor in homocysteine metabolism. Trimethylglycine may also be a preventive agent against the activation of NF-kappaB.*[7]\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eVitamin B12 (as methylcobalamin)\u003c\/strong\u003e Cyanocobalamin (the form of B12 present in many supplements) has to be converted in the liver to methylcobalamin, the form provided in Med Methylation M+. B12 is another methyl donor, and studies suggest that it supports healthy homocysteine levels already within the normal range on its own and in combination with folate.*[8] \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eVitamin B6 (as pyridoxal 5'-phosphate)\u003c\/strong\u003eThis coenzyme form of vitamin B6 is the primary bioactive form. It is a coenzyme in approximately 100 enzymatic reactions.[9] Data from the Framingham Study showed an inverse association between homocysteine and good B6 status (as well as B12 and folate).*[10]\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eVitamin B2 (as riboflavin 5'-phosphate)\u003c\/strong\u003e As the principal coenzyme form of B2, riboflavin 5'-phosphate is used in many oxidative reactions. Folate and riboflavin interact to support healthy homocysteine levels already within the normal range, possibly by maximizing the catalytic activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). The effect may be unrelated to MTHFR genotype.*[11]\u003c\/p\u003e\n","brand":"MedPodLA","offers":[{"title":"Default Title","offer_id":42228387086426,"sku":null,"price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Med_Methylation_M__Methyl_Protect_60c_10540970.png?v=1756357401"},{"product_id":"med-niacin-slow-release","title":"Med Niacin Slow Release","description":"\u003cp\u003eNiacin has decades of research behind it for supporting healthy lipid levels, but the flushing that comes with standard, instant-release forms is why most people stop taking it. Med Niacin Slow Release uses a proprietary wax-coated tablet that releases over seven to eight hours instead of all at once, cutting the flush without losing the benefit.*\u003c\/p\u003e\n\u003cp\u003eFormulated for supporting healthy blood lipids and HDL cholesterol as part of a cardiovascular protocol, without the discomfort of immediate-release niacin.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e Supports the Maintenance of Healthy Blood Lipids*\u003c\/li\u003e\n\u003cli\u003eSupports Normal Carotid Intima-Media Thickness (CIMT)*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDiscussion:\u003c\/h4\u003e\n\u003cp\u003eThe cardiovascular benefits of niacin (vitamin B3) were introduced in the June 1956 issue of Mayo Clinic Proceedings.[1] More than 20 years later, the Framingham Heart Study touted the benefits of niacin on lipid metabolism. A decade later, as the study continued, researchers labeled niacin \"front-line\" cardiovascular support.[2] This status was further reinforced in 1988 when the National Cholesterol Education Program (NCEP) panel designated niacin a \"first-line therapy\" for support of specific parameters related to cardiovascular health.*[3] \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eMechanisms of Action\u003c\/strong\u003e Several mechanisms of action have been proposed for niacin. Various experimental models suggest niacin can modulate lipoprotein biosynthesis in the liver, inhibit the release of free fatty acids from adipocytes, inhibit synthesis of apo B, induce lipoprotein lipase, and help maintain the structure and function of HDL (high-density lipoprotein) by reducing the amount of apo A-1 broken down from HDL during hepatic processing.[4,5] In addition, when niacin is used with resins, it can stimulate bile flow and may therefore affect lipid biosynthesis.*[6]\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHuman Trials\u003c\/strong\u003e Since the late 1970s, studies and clinical trials, lasting from four weeks to five years with daily doses of extended-release (also known as sustained\/prolonged\/slow-release) niacin up to 3000 mg\/day, have consistently demonstrated niacin's efficacy and safety.[6] In 2004, the ARBITER 6-HALTS trial clearly demonstrated that niacin offers \u003cbr\u003etargeted support of cardiovascular health.[7] Final results of this trial, published in 2010, further demonstrated that niacin supports healthy carotid intima-media thickness (CIMT).[8] While the supportive effect niacin has on blood lipids is well documented, there has been a recent focus by NCEP and other researchers on how niacin's effect on HDL may influence cardiovascular events.[9] More well-designed studies that address innate limitations and are carried to completion are needed.* \u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eWhy Isn't Niacin More Widely Used?\u003c\/strong\u003e The two common concerns are cutaneous flushing and increased liver enzymes. Cutaneous flushing is harmless, although it can be a nuisance. Flushing is most often seen with the use of immediate\/instant-release forms of niacin and can occur with doses as low as 30 mg\/day, but it is more likely to occur with the much \u003cbr\u003ehigher doses used to support healthy blood lipids. Flushing may last 10 to 15 minutes and, rarely, but possibly, up to two hours. The proprietary wax-coated technology used in Med Niacin Slow Release tablets allows a gradual, sustained release of niacin over a seven-to-eight-hour period. This delivery dramatically reduces the flushing associated with \u003cbr\u003eimmediate-release forms. Adherence to a regimen with the special wax-coated form of niacin, as found in Med Niacin Slow Release, ranged from 88-97% in four human clinical trials.[10,11] Flushing, itching, tingling, and upper gastrointestinal side effects were minimal, but did increase when dosing was increased to 2000 mg\/day. It is important to note that Med Niacin Slow Release should not be confused with \"no-flush\" niacin, which is inositol hexanicotinate (IHN), a supplement that does not contain any free niacin and may not be as supportive of cardiovascular health as those providing nicotinic acid.*[12,13] The second concern with regard to liver enzyme elevation was first elucidated by the results of McKenney's study, published in 1994 in the Journal of the American Medical Association (JAMA), wherein subjects received 3000 mg\/day of niacin over an extended period of time.[14] In April 2004, McKenney retracted his earlier warnings about the harmful effects of niacin and publicly supported its unique benefits.[15] Although they generally do not enter an unhealthy range, liver enzymes may increase when initiating niacin therapy, especially in amounts greater than 1000 mg\/day. Enzyme levels return to normal promptly after cessation of niacin.*[15]\u003c\/p\u003e\n","brand":"MedPodLA","offers":[{"title":"Default Title","offer_id":42228415266906,"sku":null,"price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/MedNiacinSlowRelease_NiaVasc120c_10540970.png?v=1756358436"},{"product_id":"med-omega-premium","title":"Med Omega Premium","description":"\u003cp\u003eMost fish oil has to be broken down by digestion before your body can use it, which is a problem if digestion is already a weak link. Med Omega Premium uses MaxSimil®, a monoglyceride fish oil that's already in an absorption-ready form, delivering three times the EPA and DHA absorption of standard fish oil, even for people with digestive, pancreatic, or gallbladder challenges.*\u003c\/p\u003e\n\u003cp\u003eFormulated for cardiovascular, cognitive, and metabolic support, and especially useful for anyone who hasn't gotten results from a standard fish oil.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e Positively Affects the Production of Arachidonic Acid-Derived   \u003cbr\u003eEicosanoids*\u003c\/li\u003e\n\u003cli\u003eSupports Cardiovascular Health*\u003c\/li\u003e\n\u003cli\u003eSupports Healthy Mental Functioning*\u003c\/li\u003e\n\u003cli\u003eSupports Healthy Glucose and Insulin Metabolism*\u003c\/li\u003e\n\u003cli\u003eBy Supplying the Precursors EPA and DHA, it Helps the Body Generate  \u003cbr\u003eSpecialized Proresolving Lipid Mediators, Such as Resolvins and Protectins*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDiscussion:\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eMaxSimil® Patented Lipid Absorption Enhancement Technology (PLATform)\u003c\/strong\u003e The MaxSimil PLATform is a novel monoglyceride delivery system that enhances the absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. This technology has been applied to MedPodLA's Med Omega Premium formulas in order to create a unique vehicle by which to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically \u003cbr\u003eemulsifiers and are, by nature, in a readily absorbable form (Figure 1), they can bypass the body's normal fat digestion process. These qualities make Med Omega Premium an excellent method for delivering omega-3 fatty acids, especially to individuals with digestive, pancreatic, or gall bladder challenges. Studies show that MaxSimil fish oils (FO) have three times (300%) greater absorption of EPA and DHA compared to other leading fish oils.*[1-3]\u003c\/p\u003e\n\u003cp\u003eFigure 1. Monoglyceride Chemical Representation in MaxSimil Fish Oils (R1 = fatty acid)\u003c\/p\u003e\n\u003cp\u003e\u003cimg height=\"233\" width=\"342\" alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Screenshot_43.png?v=1756360692\"\u003e\u003cbr\u003e\u003cbr\u003eUnique structure: One fatty acid attached to a glycerol backbone provides two polar ends that attract water and a non-polar tail end (R1) that attracts fat, thus enabling self-emulsification of the Med Omega Premium formulas.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eReprinted with permission from Ingenutra, Inc.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eQuality \u003c\/strong\u003e\u003cbr\u003eMed Omega Premium formulas are made using proprietary MaxSimil compositions containing monoglyceride FO with no additional ingredients, carriers, or excipients. Each fish-gelatin softgel is enteric-coated, and every batch of fish oil ensures the world's highest standards for purity, potency, and freshness. The fish oil is non-GMO, certified sustainable from Scandinavia, and antibiotic-free. Additionally, it is eco-friendly because the greater absorption of EPA and DHA ultimately means that fewer grams of fish oil need to be harvested for the same benefit.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIn Vitro and In Vivo Animal Studies\u003c\/strong\u003e \u003cbr\u003eThe ability of MaxSimil-enhanced EPA and DHA to positively influence growth inhibition and apoptosis in colorectal, breast, lung, and prostate diseased cell lines was first demonstrated in a series of in vitro studies.[4-6] Researchers subsequently set out to demonstrate efficacy in animal models after oral administration. In three separate animal models, MaxSimil EPA and DHA forms showed superior activity on diseased cell-line growth inhibition and cytokine production when compared to control, corn oil, krill oil, or the parent forms ethyl ester (EE) EPA and ethyl ester (EE) DHA.[4,7,8] These in vivo animal studies proved that orally supplemented MaxSimil EPA and DHA were well-absorbed and bioactive. Researchers postulated that the observed superior effects of MaxSimil EPA and DHA forms were the result of enhanced absorption, and they set out to prove this hypothesis.*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003ePreclinical Bioavailability Studies \u003c\/strong\u003e\u003cbr\u003eThe in vivo pharmacokinetic studies in rodents involved a comparison between MaxSimil DHA FO and its parent EE DHA FO and an analysis of blood concentrations of DHA over time. The doses used were equivalent to human doses of 3 g\/day and 30 g\/day; the latter was included primarily to investigate toxicity at high doses. Researchers found that MaxSimil DHA FO had a three times (3x) higher peak concentration (6% versus 2%, \u003cbr\u003eFigure 2), a 3x higher saturation potential at the high dose (10% versus 3%), and a 3x higher absorption rate (at a 3 g\/day equivalent human dose) than its parent DHA FO. No toxicity was observed at either dose level.[1,2] This research demonstrated superior bioavailability and presumably better exposure of cells to DHA.*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eFigure 2. Preclinical Bioavailability Study in Rodents Demonstrates Superior Peak Concentration, Saturation, and Absorption of MaxSimil DHA FO Versus Its Parent DHA FO\u003c\/p\u003e\n\u003cp\u003e\u003cimg height=\"280\" width=\"491\" alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Screenshot_44.png?v=1756361206\"\u003e\u003c\/p\u003e\n\u003cp\u003eData were derived from Ingenutra, Inc.[1,2]\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eClinical Bioavailability Study \u003c\/strong\u003e\u003cbr\u003eA phase 1, double-blind, randomized, crossover, pharmacokinetic study was performed in 20 healthy adults aged between 19 and 71 years who were administered 6 g (containing 1800 mg EPA and 1200 mg DHA) per day of EE FO or MaxSimil FO.[3] Parameters studied were plasma EPA and DHA concentration (as percent of total fatty acids), Cmax, and AUC. Compared to EE EPA+DHA, the results indicated that at peak concentration, MaxSimil EPA and DHA forms were 3x higher, they reached maximum concentration faster, and maintained their plasma levels longer (Figure 3). The finding in the animal study was validated: the MaxSimil FO instantaneous absorption was 3x greater than the EE form. Likewise, the AUC over 24 hours was also more than 3x higher (P\u0026lt;.0001) for MaxSimil EPA and DHA (MaxSimil FO).*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eNot only did this study confirm the bioavailability findings in the animal study, but it also demonstrated that after 24 hours, the MaxSimil FO maintained 2-3x higher blood levels of EPA and DHA than the EE FO. This means that, given a daily dose, circulating EPA and DHA levels can be expected to ramp up over time and remain high with steadily increasing exposure of cells to EPA, DHA, and their metabolites. Based on the results of the bioavailability studies, an individual would get more EPA and DHA from MaxSimil FO than from EE FO gram for gram. Furthermore, as shown in the animal studies, one could \u003cbr\u003eanticipate enhanced effects. It is noteworthy that all 20 adults who completed the study saw their omega-3 absorption enhanced when taking the MaxSimil enhanced FO.\u003c\/p\u003e\n\u003cp\u003eFigure 3. Human Clinical Study Findings Demonstrate Superior Absorption of and Exposure to EPA and DHA as Indicated by Cmax, Tmax, and AUC\u003c\/p\u003e\n\u003cp\u003e\u003cimg height=\"592\" width=\"451\" alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Screenshot_45.png?v=1756361327\"\u003e\u003c\/p\u003e\n\u003cp\u003eReprinted with permission from Ingenutra, Inc.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eExpanding Research \u003c\/strong\u003e\u003cbr\u003eIn vitro and animal studies have demonstrated the positive effects of MaxSimil FO on airway immune response (e.g., IgE, leukocytes); the expression of COX-2, NF-kB, cytokines (e.g., IL-6, IL-8), MUC5AC, and mucin; and Ca(2+) hypersensitivity in lung tissues.[8-11] In other research, rats subjected to eight weeks of a high-fat, high-carbohydrate diet were either not supplemented or provided 3 g\/day of MaxSimil DHA. Compared to the data \u003cbr\u003efrom the non-supplemented group, the data from the MaxSimil DHA supplemented group clearly showed a positive impact on cardiovascular health parameters. Measures included blood pressure, heart rate, serum lipid levels, cytokine production, aortic wall thickness, and a DHA: AA ratio in aortic tissue, which correlated with the production of resolvin D2 and D3 metabolites.*[12]\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eA Note About Resolvins and Other EPA and DHA Metabolites \u003c\/strong\u003e\u003cbr\u003eSpecialized proresolving lipid mediators, such as resolvins, protectins, and maresins, are EPA and DHA metabolites naturally produced in vivo through enzymatic conversion of EPA and DHA. These mediators aid the body's \"clean-up\" response to the arachidonic acid cascade.[13] Rather than supplying a single molecule or metabolite, which would mirror the pharmaceutical model, Med Omega Premium fish oils provide all the benefits of EPA and DHA as well as the expected and desirable benefits of their metabolites.*\u003c\/p\u003e\n","brand":"MedPodLA","offers":[{"title":"Default Title","offer_id":42228423163994,"sku":null,"price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/MedOmegaPremium_OmegaMonoPure650EC120c_10540970.png?v=1756361478"},{"product_id":"med-glutathione","title":"Med Glutathione","description":"\u003cp\u003eMost glutathione supplements never make it into your cells, they're unstable, poorly absorbed, and often oxidized before you even take them. Med Glutathione uses Tri-Fortify®, a liposomal delivery system backed by a Penn State University study showing real increases in intracellular glutathione, not just what shows up in a blood draw.\u003c\/p\u003e\n\u003cp\u003eFormulated for antioxidant support, detoxification, and immune function, the kind of cellular-level glutathione support a basic capsule can't deliver.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eDeliver glutathione\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003einto the cell\u003c\/strong\u003e, not just into the plasma*\u003c\/li\u003e\n\u003cli\u003ePromote healthy natural killer cell function*\u003c\/li\u003e\n\u003cli\u003eImprove oxidative stress markers*\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDiscussion:\u003c\/h4\u003e\n\u003ch4\u003eOne Product. Two Flavors. Three Mechanisms of Action.\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eBolsters antioxidant action*\u003c\/li\u003e\n\u003cli\u003ePromotes detoxification*\u003c\/li\u003e\n\u003cli\u003eFortifies the immune system*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eFeatures:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003ePublished, peer-reviewed research demonstrated superior cellular absorption\u003c\/li\u003e\n\u003cli\u003eHeat stable, no refrigeration necessary- 2-year shelf life at room temperature guarantees full potency \u003c\/li\u003e\n\u003cli\u003eAvailable in great-tasting natural watermelon or orange flavor\u003c\/li\u003e\n\u003cli\u003eGMO-free\u003c\/li\u003e\n\u003cli\u003eVegan\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eWhat is liposomal glutathione?\u003c\/h4\u003e\n\u003cp\u003eGlutathione has been dubbed the \"master antioxidant\" for its ability to recycle other antioxidants in the body. Glutathione's importance in supporting overall health is documented in numerous peer-reviewed studies. These benefits include supporting healthy detoxification, promoting a healthy immune system, and moderating oxidative stress levels.*  It is also essential for brain function, metabolic and biochemical reactions such as DNA synthesis and repair, and is critical in supporting the health of organs such as the lungs and kidneys.*\u003c\/p\u003e\n\u003ch4\u003eNot all glutathione products are created equal\u003c\/h4\u003e\n\u003cp\u003eTypical glutathione capsule benefits are minimal. Absorption is fundamentally difficult due to its naturally limited bioavailability. Its unstable nature means it is often oxidized during the manufacturing processes or when exposed to heat during storage. Simply put, most products do not effectively absorb into the cells. For glutathione to be effectively utilized by the body, it must be easily absorbed.\u003c\/p\u003e\n\u003ch4\u003eTri-Fortify® - The superior liposomal glutathione\u003c\/h4\u003e\n\u003cp\u003eTo ensure maximum absorption, a liposomal solution is required. Liposomal glutathione enables greater cellular absorption in all areas of the body. Glutathione is produced by every cell; however, due to environmental stressors and toxins, the body can benefit from additional cellular support.\u003c\/p\u003e\n\u003cp\u003eTri-Fortify® is the only liposomal glutathione backed by peer-reviewed, published clinical research. Furthermore, Tri-Fortify® overcomes the common shortcomings of other supplements. We spent two years developing our unique manufacturing process to create the best liposomal glutathione supplement. Our objectives were to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvide superior intracellular absorption\u003c\/li\u003e\n\u003cli\u003eCreate a heat-stable product that does not require refrigeration.\u003c\/li\u003e\n\u003cli\u003eDevelop a flavor that both children and adults could enjoy by eliminating the strong sulfur smell and taste associated with other glutathione products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePeer-reviewed published clinical research on Tri-Fortify®\u003c\/h4\u003e\n\u003cp\u003ePenn State University conducted a 2-week human study using\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eTri-Fortify®\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eto assess changes in intracellular glutathione absorption (not just plasma levels).  Researchers also looked at natural killer cell function and oxidative stress markers.\u003c\/p\u003e\n\u003cp\u003eThe study showed significant increases in intracellular glutathione levels after just 2 weeks of use, as well as demonstrating its ability to support healthy NK cell function and oxidative stress levels.*\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6389332\/\" rel=\"noopener\" target=\"_blank\"\u003e¹\u003c\/a\u003e\u003c\/p\u003e\n\u003ch4\u003eKey insights:\u003c\/h4\u003e\n\u003ch4\u003eBolsters Antioxidant Action*\u003c\/h4\u003e\n\u003cp\u003eGlutathione is a tri-peptide composed of the three amino acids L-glutamic acid, L-cysteine, and L-glycine.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKnown as the master antioxidant because it recycles other antioxidants, such as vitamins C and E.* This is why Tri-Fortify® has so much synergy with liposomal vitamin C\u003c\/li\u003e\n\u003cli\u003eBecause glutathione exists within cells, it is in a prime position to neutralize free radicals, which can build up in cells and cause damage*\u003c\/li\u003e\n\u003cli\u003eThe potent antioxidant effect of Tri-Fortify® helps keep cells running smoothly*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePromotes Detoxification*\u003c\/h4\u003e\n\u003cp\u003eTri-Fortify® also helps support healthy liver function.  The highest amounts of glutathione are found in the liver and kidneys, which are responsible for the removal of toxic components.*\u003c\/p\u003e\n\u003ch4\u003eFortifies Immune System*\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003ePlays a critical role in the proper function of white blood cells, including T cell lymphocytes and the multiplication of lymphocytes (the cells that mediate specific immunity)*\u003c\/li\u003e\n\u003cli\u003eAdequate function of white blood cells is essential in mounting an effective immune response\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eFeatures:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003ePublished, peer-reviewed research demonstrated superior cellular absorption\u003c\/li\u003e\n\u003cli\u003eHeat stable, no refrigeration necessary\u003c\/li\u003e\n\u003cli\u003eAvailable in natural watermelon or orange flavor\u003c\/li\u003e\n\u003cli\u003eGMO-free\u003c\/li\u003e\n\u003cli\u003eVegan\u003c\/li\u003e\n\u003c\/ul\u003e\n","brand":"MedPodLA","offers":[{"title":"Default Title","offer_id":42255784837210,"sku":null,"price":75.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Image_1_MedPodLA-1.png?v=1757049811"},{"product_id":"glutaryl-by-auro-wellness","title":"Glutaryl by Auro Wellness","description":"\u003cp\u003eGlutaryl is a topical glutathione spray made by Auro Wellness, using their Auro GSH™ sub-nano delivery technology to deliver glutathione through the skin instead of through digestion. MedPodLA carries it as a non-oral option for people who want antioxidant and cellular support without taking a supplement by mouth.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eClinical Applications:\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eSupport the body's antioxidant defenses*\u003c\/li\u003e\n\u003cli\u003eSupport cellular health*\u003c\/li\u003e\n\u003cli\u003eSupport the body's natural detoxification processes*\u003c\/li\u003e\n\u003cli\u003eSupport immune function*\u003c\/li\u003e\n\u003cli\u003eSupport energy and healthy aging*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eDirections:\u003c\/h4\u003e\n\u003cp\u003eApply four sprays to clean skin, twice daily. Rub in until dry and leave on for at least 45 minutes. Apply to a non-hairy area such as the abdomen.\u003c\/p\u003e\n\u003ch4\u003eIngredients:\u003c\/h4\u003e\n\u003cp\u003ePurified water, glutathione, cyclodextrin, ascorbic acid, sodium hydroxide, dexpanthenol, Leuconostoc\/radish root extract ferment filtrate, Japanese honeysuckle flower extract, honeysuckle flower extract, Populus tremuloides bark extract, potassium sorbate, gluconolactone.\u003c\/p\u003e\n\u003ch4\u003eFeatures:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eMade by Auro Wellness using Auro GSH™ sub-nano delivery technology\u003c\/li\u003e\n\u003cli\u003eThird-party lab tested\u003c\/li\u003e\n\u003cli\u003eNon-comedogenic\u003c\/li\u003e\n\u003cli\u003eFree of parabens, sulfates, perfumes, mineral oil, artificial preservatives, artificial colors, gluten, and dairy\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eMedPodLA also carries Med Glutathione, our oral liposomal option backed by a Penn State University study. Glutaryl is a topical alternative for those who prefer not to take glutathione by mouth.\u003c\/em\u003e\u003c\/p\u003e","brand":"Auro Wellness","offers":[{"title":"Default Title","offer_id":44022572154970,"sku":null,"price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/8684\/7066\/files\/Glutaryl_94283fe1-b285-4714-9124-69c6c76509d8.png?v=1788723465"}],"url":"https:\/\/shop.medpodla.com\/collections\/heart-metabolic-cellular-health.oembed","provider":"MedPodLA","version":"1.0","type":"link"}